We provide specialized winterization services to safeguard your pool during the off-season, and when spring arrives, we handle the thorough opening process.
Welcome to the World of Sulfonation
We provide specialized winterization services to safeguard your pool during the off-season, and when spring arrives, we handle the thorough opening process.
Welcome to the World of Sulfonation
P-Toluenesulfonyl Chloride (PTSC), also known as Tosyl Chloride or TsCl, is an aromatic sulfonyl chloride used as a versatile reagent and intermediate in organic synthesis and specialty chemical manufacturing.
AAOL supplies PTSC for industrial applications where controlled sulfonylation chemistry, product consistency and reliable technical documentation are important.
PTSC is widely used to convert suitable hydroxyl-containing compounds into tosylate derivatives, which can serve as useful intermediates in multi-step organic synthesis. It is also used in selected pharmaceutical, agrochemical, dye and specialty chemical processes.
CAS Number
98-59-9
FORMULA
C₇H₇ClO₂S
MOLECULAR WEIGHT
190.65
PURITY
>98%
STORAGE
Cool, dry place under inert atmosphere
SHELF LIFE
12 Months
Corrosive
C₇H₇ClO₂S
98-59-9
• Pharmaceutical Intermediate Synthesis
• Organic Synthesis
• Agrochemical Intermediates
• Research & Process Development
• Fine & Specialty Chemicals
• Dye & Pigment Intermediates
P-Toluenesulfonyl Chloride is an important sulfonylating reagent used in a wide range of synthetic chemistry processes.
Its sulfonyl chloride functionality makes it useful for producing tosylate and sulfonamide derivatives and for introducing the p-toluenesulfonyl group into suitable organic molecules.
In chemical manufacturing, PTSC may be used as a reagent or intermediate in processes involving:
• organic synthesis
• pharmaceutical intermediates
• fine and specialty chemicals
• agrochemical intermediates
• dye and pigment intermediates
• functional-group transformation
• process-development chemistry
PTSC is particularly well known in synthetic chemistry for converting alcohols and related hydroxyl-containing compounds into tosylates, which are useful leaving-group derivatives in subsequent transformations. Sigma-Aldrich describes p-toluenesulfonyl chloride as a reagent commonly used to convert hydroxyl groups into sulfonates, while TCI lists it as a high-purity synthetic reagent.
For industrial users, selection should be based not only on reaction compatibility but also on product assay, impurity profile, moisture control, storage conditions and batch documentation.
Verified Research Batch
P-Toluenesulfonyl Chloride
98-59-9
Crystalline Powder
PTSC / TsCl
C₇H₇ClO₂S
190.65 g/mol
C₇H₇ClO₂S
White to off-white
67–71°C
128°C, closed cup
1.49
800 kg/m³
Soluble in alcohols, benzene and ether
>98% PTSC
Substance / organic sulfonyl chloride
Every production batch undergoes rigorous analytical verification to ensure compliance with internal quality specifications and customer requirements. Testing protocols support product consistency, catalytic performance, purity verification, and manufacturing reliability.
PTSC is widely used as a sulfonylating reagent in organic chemistry.
One of its best-known roles is the conversion of alcohols or phenols into tosylate derivatives, which can function as improved leaving groups in subsequent substitution or elimination reactions.
Typical Roles:
✓ Tosylation of Alcohols
✓ Preparation of Sulfonate Esters
✓ Functional-group Activation
✓ Multi-step Synthesis
PTSC is used in selected pharmaceutical and intermediate manufacturing routes where sulfonylation or preparation of activated intermediates is required.
Its suitability depends on the chemistry, impurity requirements and downstream process.
Key Considerations:
✓ Process Compatibility
✓ Impurity Profile
✓ Batch Documentation
✓ Moisture Control
✓ Downstream Purification
PTSC is used in specialty chemical synthesis where controlled introduction of the p-toluenesulfonyl group is required.
It can act as a reagent or intermediate in the preparation of value-added organic compounds and functionalized intermediates.
Key Benefits:
✓ Specialty Intermediates
✓ Synthetic Reagents
✓ Custom Synthesis
✓ Process Chemistry
Sulfonyl chloride chemistry may be used in selected agrochemical synthesis pathways and intermediate manufacturing.
PTSC can be relevant where sulfonylation or downstream functional-group conversion is required.
Process Value:
✓ Versatile Intermediate Chemistry
✓ Compatibility with Multi-step Synthesis
✓ Useful Functional-group Activation
PTSC is also used in selected synthesis routes for dyes, pigments and related intermediates.
Its role depends on the target molecule and reaction pathway.
Typical Function:
✓ Sulfonylating Reagent
✓ Intermediate Formation
✓ Functionalization of Organic Molecules
PTSC is commonly used in laboratory and process-development chemistry for:
✓ Reaction Screening
✓ Tosylation Studies
✓ Intermediate Synthesis
✓ Method Development
✓ Scale-up Assessment
PTSC should be handled as a corrosive industrial chemical.
AAOL’s MSDS identifies the following classifications:
⦿ H290 — May be corrosive to metals
⦿ H314 — Causes severe skin burns and eye damage
⦿ H317 — May cause an allergic skin reaction
⦿ H318 — Causes serious eye damage
⦿ H335 — May cause respiratory irritation
Appropriate controls include:
⦿ Chemical splash goggles or face protection
⦿ Protective gloves
⦿ Protective clothing
⦿ Suitable respiratory protection where inhalation risk exists
⦿ Adequate local and general ventilation
The MSDS calls for protective gloves, protective clothing, eye/face protection, and ventilation controls appropriate to exposure conditions.
Eye Contact
Rinse immediately with plenty of water for at least 15 minutes and obtain medical attention.
Skin Contact
Remove contaminated clothing and rinse immediately with plenty of water for at least 15 minutes. Chemical burns require medical attention.
Inhalation
Move the affected person to fresh air and obtain medical attention where required.
Ingestion
Rinse the mouth. Do not induce vomiting unless directed by medical personnel and seek medical attention.
These actions are summarized from AAOL’s MSDS and should always remain subordinate to the current SDS instructions.
Avoid uncontrolled release into drains or the aquatic environment.
Spillage and waste should be collected and disposed of through approved procedures in accordance with applicable regulations.
Store in a cool, well-ventilated place, away from high temperature and direct sunlight.
Keep the product in its original container and protect the packaging from damage
PTSC should be protected from moisture.
Our PTSC states:
Store in a corrosion-resistant container with a resistant inner liner.
Our PTSC also identifies mild steel, stainless steel and aluminium as incompatible materials and states that the material may be corrosive to metals.
PTSC is described as stable at normal ambient temperatures when stored and used under the recommended conditions.
Our products are sealed in industrial-grade, moisture-resistant packaging for long-term product stability and safe transportation. Always ensure the seal is intact upon receipt. If the seal is compromised, contact our technical support team immediately.
Need custom documentation or batch-specific analysis?
PTSC is a technically important intermediate, so industrial buyers should evaluate more than product availability alone.
AAOL supports PTSC supply with a focus on controlled product quality, documentation and industrial handling requirements.
AAOL can support discussions around technical requirements, documentation, order quantity, packaging and recurring procurement.
Supply against defined product parameters helps procurement and production teams evaluate suitability for repeat use.
Relevant documentation may include Safety Data Sheet (SDS), Certificate of Analysis (COA), Technical specification / TDS and supporting quality information.
PTSC is corrosive and moisture-sensitive. Appropriate packaging, storage and handling controls are therefore essential throughout supply and use. The AAOL MSDS classifies the product as corrosive to metals, corrosive to skin and eyes, a skin sensitizer and a respiratory irritant.
Today’s procurement teams, R&D scientists, and manufacturing organizations require more than a product specification sheet. They need reliable supply partners capable of delivering quality assurance, regulatory support, technical expertise, and manufacturing consistency.
AAOL provides a comprehensive product support ecosystem built around quality, transparency, and long-term customer partnerships. This approach enables organizations to confidently integrate PTSC into research programs, pilot operations, and commercial manufacturing processes.
Supports pharmaceutical synthesis, specialty chemical manufacturing, polymer production, resin systems, catalyst development, and advanced chemical processing operations.
Produced using advanced sulfonation technologies supported by dedicated manufacturing facilities, pilot plant capabilities, and rigorous quality control systems.
Every batch undergoes analytical verification for purity, consistency, and performance reliability to support critical industrial applications.
Available in laboratory packs, pilot-scale quantities, industrial packaging formats, and bulk supply configurations with export-ready logistics support.
Technical documentation packages are available to support procurement evaluations, compliance reviews, and customer qualification processes.
Leveraging extensive sulfonation expertise, AAOL supports customized manufacturing requirements, application-specific specifications, and long-term supply partnerships.
The sulfonyl chloride group enables PTSC to react with suitable oxygen- and nitrogen-containing nucleophiles under controlled reaction conditions.
PTSC is widely associated with formation of tosylate derivatives from alcohols and phenols.
AAOL’s MSDS describes PTSC as a white to off-white crystalline powder, with a melting range of 67–71°C.
The MSDS instructs users to protect PTSC from moisture and notes that the product is air- and light-sensitive and should be stored under inert gas.
PTSC requires careful industrial handling because it can cause severe skin burns and eye damage and may cause respiratory irritation or allergic skin reaction.
Our MSDS classifies the material for transport as UN 3261, Corrosive Solid, Acidic, Organic, N.O.S., Class 8, Packing Group III.
The role of P-Toluenesulfonyl Chloride is particularly important in reactions where a hydroxyl group must be transformed into a more reactive derivative.
Alcohol hydroxyl groups are generally poor leaving groups under many reaction conditions. Conversion into a tosylate changes this behavior and can make subsequent substitution or elimination chemistry more practical.
This is one of the important characteristics of Para-Toluenesulfonyl Chloride as a synthetic reagent.
PTSC is therefore widely recognized as a useful reagent for alcohol activation, sulfonate ester formation, sulfonamide synthesis, preparation of reactive intermediates and multi-stage organic synthesis.
In Stock
| Product | P-Toluenesulfonyl Chloride |
|---|---|
| Abbreviation | PTSC / TsCl |
| CAS | 98-59-9 |
| Purity | >98% |
| Form | White to off-white crystalline powder |
| Documentation | SDS / COA / Specification |
| Supply | Industrial quantities |
| Packaging | REQUIRES TDS / SALES CONFIRMATION |
Pricing depends on purity requirements, packaging format, application suitability, order quantity, export destination, and logistics specifications.
Whether your requirement involves laboratory research, pilot-scale evaluation, process development, or commercial manufacturing, AAOL delivers dependable PTSC supply supported by responsive technical assistance and consistent production capabilities.
Research Packaging
Per Unit
Research Packaging
Per Unit
Research Packaging
Per Unit
Research Packaging
Per Unit
PTSC stands for P-Toluenesulfonyl Chloride, also known as Tosyl Chloride or TsCl. It is an aromatic sulfonyl chloride used as a reagent and intermediate in organic synthesis.
The CAS number is 98-59-9.
The molecular formula of P-Toluenesulfonyl Chloride is C₇H₇ClO₂S.
PTSC is widely used as a sulfonylating and tosylating reagent in organic synthesis and in selected pharmaceutical, fine-chemical, agrochemical and specialty-chemical intermediate manufacturing.
PTSC can convert suitable hydroxyl-containing compounds into tosylate derivatives. Tosylates are useful synthetic intermediates because they can function as better leaving groups in subsequent chemical reactions.
Yes. AAOL’s MSDS instructs users to protect the material from moisture and store it under inert gas in tightly closed containers.
Yes. It is classified as corrosive and can cause severe skin burns and eye damage. It may also cause allergic skin reaction and respiratory irritation.
AAOL’s current MSDS identifies the material as containing more than 98% P-Toluenesulfonyl Chloride. The latest TDS or COA should be used to confirm the applicable commercial specification.
AAOL supplies P-Toluenesulfonyl Chloride (PTSC) for industrial organic synthesis and specialty chemical applications.
If you are evaluating a Para Toluene Sulfonyl Chloride manufacturer, supplier or exporter, share your required specification, quantity, packaging and delivery location with the AAOL team.
Our team can support discussions around:
